So, why would you never use Sermorelin powder? Well…there are many reasons why bodybuilders and athletes may not
ever touch this peptide, but we will get into that later. Let me start
off by saying Sermorelin is actually known to us by the name GRF (1-29).
We touched on this in my last articlewhen we discussed CJC 1295 and
how CJC 1295 without DAC is really modified version of GRF (1-29) aptly
named MOD GRF (1-29). The original GFR (1-29) is, in fact, the root of
the molecule and that remaining peptide containing the first 29 amino
acids is actually what is responsible for stimulating pituitary
response. The name Sermorelin is the prescription drug name and this
alone is why it is so widely prescribed by hormone replacement therapy
clinics (HRT).
Introduction
Even though in bodybuilding circles we don't hear much about Sermorelin, this doesn't mean that this peptide does not have its uses.
In fact, anti-aging and hormone replacement clinics have been
prescribing it for years because it works as a clean GHRH. The problem
for the bodybuilder or athlete is that it has a very short half-life of
about ten (10) minutes. This becomes an unattractive feature when
compared to the half-life of MOD GRF (1-29) (CJC 1295 without DAC),
which comes in around 30 minutes. Despite its short window, it does
bind quite effectively to the pituitary receptors. The other main down
side associated with its very short half life is that it is quickly
broken down by blood enzymes within minutes. This is why a GHRH peptide
with a half life of 30 minutes or longer is desirable, since it will
survive the blood enzyme death and allow it to circulate the body
looking for hormone receptors to bind to.
So, why would bodybuilders or athletes want to utilize Sermorelin over other peptides that have longer half lives like MOD GRF (1-29) or
CJC 1295 with DAC? To put it simply, you could easily work this into a
multi-dosing protocol along with you other long acting GHRH's and
GHRP's. Let's look at Sermorelin's known positive effects like:
increased lean body mass, reduced fat, increased strength, improved
recovery, better sleep, strengthenining of the heart, enhancing of the
immune system and increases IG1 production. Yes, while the ability of
Sermorelin to act is short, it still promotes all of these factors
stated above. Not to mention it also has the ability to increase
protein synthesis, promote growth of all internal organs with the
exception of the brain and promote and increase in liver glucogenesis.
Despite its tiny half life, Sermorelin's ability to increase IG1 in the
blood stream will only further increase the function of the metabolism
and the growth of new cells in muscles, bones and organs. Sermorelin is
heavily pushed by HRT clinics and is often referred to as the
anti-aging peptide since it is very good at reversing some of the
effects of aging in adults.
Dosage and Usage
Sermorelin, along with the other peptides you will use, comes as a delicate lyophilized powder that should be kept out of the light and in a
cool dry place. Reconstitution is done with bacteriostatic water (BC
water) or sodium chloride meant for injection. Injections can be
administered one hour before workout at a dose of 200mcg-300mcg.
Normally, Sermorelin injections are taken before bed at around 300mcgs.
Of course, as with any GHRH, you will want to use this peptide
alongside a GHRP like GHRP-2 or Ipamorelin for maximum release of GH
stores. Ideally, though user could still benefit from using a GHRH like
CJC 1295 with DAC and a GHRP like Ipamorelin throughout the day and
then utilize Sermorelin as a pre-bed timed dose. Do not discount
Sermorelin as simply an anti-aging peptide. It can still help promote
the growth of lean body mass and increase the availability of IGF-1 in
the blood stream.
Sermorelin is pretty mild in terms of side effects, but, like most peptides, it has the ability to bring on head rush, flush feeling, some
swelling at injection site, dizziness, and nausea. I could not find any
cases where prolactin or cortisol levels were elevated by the use of
Sermorelin. As always, listen to your body and follow a dosing protocol
that is in tune with you goals.
Conclusion
While athletes and bodybuilders are not going crazy on the forum's over Sermorelin, there is no doubt that it has its place in the
community as an anti-aging agent and perhaps another tool to use within
your current peptide protocol. The fact that it has been legitimized
within the HRT community and is available via prescription also means
that the effects attributed to this peptide have been wellresearched,
studied and proven to work.
