Basic Info.
CAS:33515-09-2
Sequence:P-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
MF:C55-H75-N17-O13
MW:1182
Purity:99%
Specification:2mg/vial, 10mg/vial
Appearance:White Lyophilized Powder
Standard:USP
Storage: Lyophilized peptides although stable at room temperature for 3
months, should be stored desiccated below -18 C. Upon reconstitution of
the peptide it should be stored at 4 C between 2-21 days and for future
use below -18 C.
Gonadorelin Acetate powder,Gonadorelin powderDescription
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior
pitutitary. In the pituitary GnRH stimulates synthesis and release of
FSH and LH, a process that is controlled by the frequency and amplitude
of GnRH pulses, as well as the feedback of androgens and estrogens. The
pulsatility of GnRH secretion has been seen in all vertebrates, and it
is necessary to ensure a correct reproductive function. Thus a single
hormone, GnRH, controls a complex process of follicular growth,
ovulation, and corpus luteum maintenance in the female, and
spermatogenesis in the male. Its short half life requires infusion pumps
for its clinical use.
Gonadorelin USAGE
For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual
gonadotropic function of the pituitary following removal of a pituitary
tumor by surgery and/or irradiation.
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from
the anterior pitutitary. In the pituitary GnRH stimulates synthesis and
release of FSH and LH, a process that is controlled by the frequency
and amplitude of GnRH pulses, as well as the feedback of androgens and
estrogens. The pulsatility of GnRH secretion has been seen in all
vertebrates, and it is necessary to ensure a correct reproductive
function. Thus a single hormone, GnRH, controls a complex process of
follicular growth, ovulation, and corpus luteum maintenance in the
female, and spermatogenesis in the male. Its short half life requires
infusion pumps for its clinical use
Systemic - Like naturally occurring releasing hormone (GnRH), gonadorelin primarily stimulates the
synthesis and release of luteinizing hormone (LH) from the anterior
pituitary gland. Follicle-stimulating hormone (FSH) production and
release is also increased by gonadorelin, but to a lesser degree. In
prepubertal females and some gonadal function disorders, the FSH
response may be greater than the LH response. For the treatment of
amenorrhea, delayed puberty, and infertility the administration of
gonadorelin is used to simulate the physiologic release of GnRH from the
hypothalamus in treatment of delayed puberty, treatment of infertility
caused by hypogonadotropic hypogonadism, and induction of ovulation in
those women with hypothalamic amenorrhea. This results in increased
levels of pituitary LH and FSH, which subsequently stimulate the gonads
to produce reproductive steroids.
