Celiprolol powder General Description
Celiprolol powder is a medication in the class of beta blockers, used in the treatment of
high blood pressure. It has a unique pharmacology: it is a selective ß1
receptor antagonist, but a ß2 receptor partial agonist. It is also a
weak a2 receptor antagonist. Celiprolol powder is believed to provide
clinical benefit for people with vascular Ehlers–Danlos syndrome by
promoting normal collagen synthesis in the blood vessels, and by
shifting the pressure load away from the vessels most prone to
dissection and rupture. In 2019, a new drug application (NDA) for
celiprolol was denied by the Food an the U.S. Food and Drug
Administration (FDA), instead calling for an “adequate and
well-controlled” trial to determine whether celiprolol reduced the risk
of clinical events in patients with vEDS. Celiprolol is a vasoactive
beta-1 selective adrenoceptor antagonist with partial beta-2 agonist
activity. The beta-2 agonist activity is thought to account for its mild
vasodilating properties. It lowers blood pressure in hypertensive
patients at rest and on exercise. The effects on heart rate and cardiac
output are dependent on the pre-existing background level of sympathetic
tone. Under conditions of stress such as exercise, celiprolol
attenuates chronotropic and inotropic responses to sympathetic
stimulation. However, at rest minimal impairment of cardiac function is
seen. Before you start the treatment, read the manufacturer’s printed
information leaflet from inside the pack. It will give you more
information about celiprolol and will provide you with a full list of
the side-effects which you may experience from taking it. Take
celiprolol exactly as your doctor tells you to. There are two strengths
of tablet – 200 mg and 400 mg. It is usual to start by taking one 200 mg
tablet daily, although your doctor may later increase this to the 400
mg strength tablet. You should take the tablet first thing in the
morning, preferably ‘on an empty stomach’. This means that you should
take the tablet at least 30 minutes before you have breakfast, or wait
until two hours after you have eaten. Swallow the Celiprolol: A Unique
Selective Adrenoceptor Modulator. Celiprolol is a ß-blocker with a
unique pharmacologic profile: it is a ß1-andrenoceptor antagonist with
partial ß2 agonist activity. Given this combination of effects,
celiprolol may be better described as a selective adrenoreceptor
modulator. It has antihypertensive and antianginal properties and is
indicated for those uses in various countries around the world. In the
United States, however, the proposed indication for this drug will be
for the treatment of vascular type Ehlers-Danlos syndrome, a rare
connective tissue disorder characterized by fragile arterial structure
and an increased risk of life-threatening vascular complications. By
reducing heart rate and pulsatile pressure, celiprolol may reduce the
mechanical stress on collagen fibers within the arterial wall and be of
benefit in patients with vascular type Ehlers-Danlos syndrome. The
largest investigation of celiprolol in vascular Ehlers-Danlos syndrome
was prematurely terminated due to significant benefit with celiprolol in
reducing arterial events in patients with this condition. Celiprolol,
therefore, represents a ß-blocker that is unique from others in its
class in both its pharmacology and clinical applications.
