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????:????????????P450 3A4,1A2?2C9 ?2C19?2D6 ?(????)?2C9(????), ???????????????????????????:??????????30mg?????(?????????? P450???)700mg,?????????????66%???????100mg?????P450 3A4??????????(500mg,?? ??,?5?????)???,????????????(AUC)??182%;??????100mg????CYP450 3A4???HIV??????saquinavir??, ?????(120mg,????),????Cmax??140%,AUC??210%,???????????????;?????????????CYP450 3A4???, ????????;??CYP450 3A4??? (?????????????)???(50mg)???????(150mg)?????????????????????????0.08%?,????(50mg)???????????[img width=400,height=400]https://www.ds52019.com/images/upload/Image/127_P_1560415466088_%E5%89%AF%E6%9C%AC(3).jpg[/img][img width=15,height=15]data:image/gif;base64,R0lGODlhAQABAPABAP///wAAACH5BAEKAAAALAAAAAABAAEAAAICRAEAOw==[/img]?????(100mg)?? ?HIV??????saquinavir? ritonavir?????????,?????????????(100mg)?????5mg?10mg,? ????????????8mmHg,??????????7mmHg?????CYP450 2C9????????(250mg)????(40mg)??????????????????(50mg)???????(150mg)?????????????????????????0.08%?,????(50mg)???????????????(100mg)?? ?HIV??????saquinavir? ritonavir?????????,?????CYP450 3A4?????????????????????????,???????????,?????????,???????.jpg)
[img width=15,height=15]data:image/gif;base64,R0lGODlhAQABAPABAP///wAAACH5BAEKAAAALAAAAAABAAEAAAICRAEAOw==[/img]?????:??? ??? ????? ???? ???? ???? ????? ??? ??? ?????????:?????? www.ds52019.com 24h????LINE:ds52019 ????!
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