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precursors of mood-regulating neurotransmitters such as serotonin and dopamine,
amino acids are considered to hold potential in treatingdepression.
Neurotransmitter precursors are the subject of ongoing research.So why is this
topic relevant to primary care medicine? Patients have taken matters into their
ownhands. Patients are self-treating their depression with amino acid
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overall health. The amino acid precursors tryptophan,tyrosine uggs bailey button bling sale , 5-hydroxytryptophan, and L-dopa are readily available as supplements at doses that exceed feasible dietary intake.
Amino acids supplements have less potential for harm and larger
therapeuticeffect when their use is physician-guided.This chapter presents the
bundle damage theory of depression to probe the biologic basis of amino acid
therapy. It offers primary care physicians a treatment protocol that implements
laboratory testing toguide dosing; explains the potential side effects and how
these can be minimized; offers quality regulation in product selection; and
presents a protocol for simultaneous use of medication and nutrients inthe
treatment of clinical depression.II. EPIDEMIOLOGYDepression is a global problem.
The World Health Organization notes:32 Nearly 5??0% of persons in a community at
a given time are in need of help for depression. As muchas 8??0% of persons
carry the risk of developing depression during their lifetime. The average age
of the onset for major depression is between 20 and 40 years. Women have higher
rates of depression thanmen. Race or ethnicity does not infl uence the
prevalence of depression. World wide depression is the fourth leading cause of
disease burden, accounting for 4.4% of total Disability-Adjusted
Life-Years(DALYs) in the year 2000. It causes the largest amount of non-fatal
burden. Disability from depression world wide is increasing. In 1990, the total
years lived with disability (YLD) was 10.7%. By 2000, theYLD had increased to
12.1% worldwide.33 Mental health conditions have a tendency to move upwards in
ranking, while ranked as the fourth leading cause of disease burden in
2000 uggs bailey button bling zwart , it is expected thatdepression will move to second place by 2020, second only to heart disease.34 Population surveys
suggest that while the incidence of depression is higher in the
developedcountries of North America and Europe than in other regions.