Compound 7P powder (1890208-58-8)

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freemexy

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Raw Compound 7P powder which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and
retina. in an animal model of optic nerve injury, Raw Compound 7P powder
was shown to induce growth of gap-43 positive axons, indicating that
the in vitro neurite outgrowth activity of Raw Compound 7P powder
translates into stimulation of axon regeneration in vivo.Compound 7P powder

Raw Compound 7P powder which promotes neurite outgrowth of cultured
primary neurons derived from the hippocampus, cerebral cortex, and
retina.

In an animal model of optic nerve injury, Raw Compound 7P was shown to
induce growth of gap-43 positive axons, indicating that the in vitro
neurite outgrowth activity of Raw Compound 7P translates into
stimulation of axon regeneration in vivo.
Compound 7p was developed as one in series of compounds with the aim of
identifying dual-acting thromboxane receptor antagonist/synthase
inhibitors .

In fact compound 7p shows selectivity for prostaglandin I2 synthase (PTGIS , CYP8A1) over thromboxane synthase (CYP5A1) .
Raw Compound 7P (2-[(2-methoxyphenyl)[(4-methyl phenyl) sulfonyl]
amino]-N-(4-methoxy-3-pyridinyl) acetamide) powder which promotes
neurite outgrowth of cultured primary neurons derived from the
hippocampus, cerebral cortex, and retina. in an animal model of optic
nerve injury, Raw Compound 7P powder was shown to induce growth of
gap-43 positive axons, indicating that the in vitro neurite outgrowth
activity of Raw Compound 7P powder translates into stimulation of axon
regeneration in vivo.further optimization of Raw Compound 7P powder and
elucidation of the mechanisms by which it elicits axon regeneration in
vivo will provide a rational basis for future efforts to enhance
treatment strategies.

Compound 7p (2-[(2-methoxyphenyl)[(4-methyl phenyl) sulfonyl]
amino]-N-(4-methoxy-3-pyridinyl) acetamide) showed the highest activity
against cervical cancer cells. In a nude mouse xenograft model
inoculated with HeLa cells, 7p showed dose-dependent inhibition of
cervical tumour growth. Histopathological examination of excised
tumour-bearing tissues showed that 7p improved the microstructure in a
dose-dependent manner. Compound 7p also increased the proportions of
HeLa cells in G0/G1 and S-phase and significantly decreased that of
G2/M-phase. The effects of 7p on C-caspase-3, C-caspase-9, Bcl-2 and Bax
expression in HeLa cells were also determined.

Posted 30 Oct 2019

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